Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL

Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL

Blog Article

Abstract RIPK3 was reported to play an important role in the protection against influenza A virus (IAV) in vivo.Here we show that the requirement of RIPK3 for protection against IAV infection in vivo is only apparent within a limited dose range of IAV challenge.We found that this protective outcome is independent from RIPK3 Curling - Shoes - Womens kinase activity and from MLKL.This shows that platform function of RIPK3 rather than its kinase activity is required for protection, suggesting that a RIPK3 function independent of necroptosis is implicated.In line with this finding, we show that FADD-dependent apoptosis has a crucial additional effect in protection against High Density Roll IAV infection.

Altogether, we show that RIPK3 contributes to protection against IAV in a narrow challenge dose range by a mechanism that is independent of its kinase activity and its capacity to induce necroptosis.